An up to date basic introduction to the blood brain barrier which starts with a clear description of the key historical experiments which have led to the concept of this multi faceted barrier mechanism there are sections on the morphology of the barrier basic transport kinetics and carrier meditated processes. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood transport kinetics and carrier mediated processes are described and the mechanism by which molecules can cross the barrier is discussed. For instance studies suggest a leaky blood brain barrier allows too many white blood cells into the brains of people with multiple sclerosis ms with access to the brain these cells attack myelin the insulating coating between nerve cells leading to the diseases devastating symptoms developing drugs that can penetrate blood brain barrier. In the late 1960s the advances in technology allowed scientists to capture pictures of the blood brain barrier using electron microscopes this instrument can see things that are thousands of times smaller than what can be seen with regular light microscopes
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